Mukd-546 Exclusive

| Cell Line | Mutation | IC₅₀ (nM) | |-----------|----------|-----------| | MIA‑PaCa‑2 | KRAS‑G12C | 45 ± 3 | | PANC‑1 | KRAS‑G12D | 62 ± 5 | | A375 | BRAF‑V600E | 28 ± 2 | | SK‑MEL‑28 | BRAF‑V600E | 32 ± 3 | | A549 | KRAS‑G12S | 78 ± 6 | | HCT‑116 | KRAS‑G13D | 71 ± 5 | | Others (non‑mutated) | – | 210‑480 |

Data expressed as mean ± SD. Comparisons between groups performed using two‑tailed Student’s t‑test or ANOVA with Tukey post‑hoc correction; p < 0.05 considered significant. mukd-546