In many Firmicutes, YycJ is proposed to be the sole exonuclease required to support a full mismatch repair process, correcting errors that occur during DNA replication.
Because the WalRK system is essential for the survival of several major human pathogens, YycJ and its operon partners are prime targets for the development of new antibacterial therapies. In many Firmicutes, YycJ is proposed to be
yycj
It acts by removing mismatched nucleotides from the newly synthesized DNA strand, thereby preventing mutations from becoming permanent in dividing cells. The WalRK (YycFG) Operon In many Firmicutes
Research indicates that YycJ contains a putative metal-binding site within a β-lactamase fold , suggesting it may function as a metallo-hydrolase. In many Firmicutes, YycJ is proposed to be
In many Firmicutes, YycJ is proposed to be the sole exonuclease required to support a full mismatch repair process, correcting errors that occur during DNA replication.
Because the WalRK system is essential for the survival of several major human pathogens, YycJ and its operon partners are prime targets for the development of new antibacterial therapies.
yycj
It acts by removing mismatched nucleotides from the newly synthesized DNA strand, thereby preventing mutations from becoming permanent in dividing cells. The WalRK (YycFG) Operon
Research indicates that YycJ contains a putative metal-binding site within a β-lactamase fold , suggesting it may function as a metallo-hydrolase.