Unlike traditional karyotyping, which relies on manual microscopy, the modern Arizona workflow is heavily digitized. Due to the sheer geographic spread of the state—from Flagstaff to Yuma—tele-genetics is mandatory.
One of the proudest successes of the "Arizona method" involves hearing loss. Arizona has a higher incidence of genetic non-syndromic hearing loss linked to specific Connexin 26 and 30 mutations. While a karyotype doesn't sequence genes, it looks for large structural changes surrounding those loci. arizona karyotyping