Heparin impairs the production of , a hormone produced by the adrenal cortex (specifically the zona glomerulosa ). Aldosterone is essential for regulating sodium and potassium levels. When its production is blocked, the body loses its primary mechanism for excreting potassium, leading to hyperkalemia.
Aldosterone suppression can be observed as early as four days after beginning therapy. Risk Factors for Heparin-Induced Hyperkalemia how does heparin cause hyperkalemia
The decrease in aldosterone levels leads to hypoaldosteronism (low levels of aldosterone). Without sufficient aldosterone, the kidneys decrease their excretion of potassium, leading to retention. Pathophysiology Breakdown Heparin impairs the production of , a hormone