Saving your game progress is essential in Resident Evil 4 PC, as it allows you to pick up where you left off in case you need to stop playing or if you encounter a game-ending situation. With a save game, you can resume playing from a previous checkpoint, rather than having to start over from the beginning.
This often happens if you use mods. Ensure your mods are updated to the latest version, or try launching the game with mods disabled to see if the save file becomes readable again. Steam Cloud Sync Errors save game resident evil 4 pc