Adobezii -

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Background: Chronic inflammation underlies numerous autoimmune and metabolic disorders. There is a continued need for small molecules targeting multiple pro-inflammatory cytokines without immunosuppressive toxicity. The synthetic flavonoid derivative adobezii (IUPAC: 5,7-dihydroxy-2-(4-methoxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one) was identified through computational screening against the TNF-α and IL-6 binding pockets. Methods: Molecular docking and MD simulations (100 ns) predicted stable binding to both targets. In vivo, acute inflammation was induced in BALB/c mice via intraplantar carrageenan injection. Adobezii (5, 10, 20 mg/kg, oral) was administered 1 h prior. Paw edema, myeloperoxidase activity, and serum cytokines were measured. Results: Adobezii dose-dependently reduced paw swelling (max 68% at 20 mg/kg, p<0.01), suppressed TNF-α and IL-6 by 74% and 69% respectively, and decreased neutrophil infiltration. No hepatotoxicity or weight loss was observed. Conclusion: Adobezii represents a promising dual cytokine inhibitor scaffold for further optimization in rheumatoid arthritis models.