The device is widely used with Axon Instruments patch-clamp amplifiers, such as the MultiClamp 700B or Axopatch 200B, to ensure clean data acquisition even in electrically noisy environments. Axon Digidata 1550B Low-Noise System plus HumSilencer

A standard low-noise digitizer without the HumSilencer feature.

The Digidata 1550B is controlled via (specifically versions 10.7 and later).

October 26, 2023 Subject: Operational Overview and Specification Analysis of the Digidata 1550B with HumSilencer Technology.

Users should ensure they are running the latest version of pCLAMP software to utilize the full adaptive capabilities of the HumSilencer feature.

Electrophysiology labs are often plagued by electromagnetic interference (EMI) from building wiring, lighting, and equipment. This manifests as a 50 Hz or 60 Hz "hum" (depending on geographical location) overlaying the biological signal. Traditional noise removal involves manual grounding, Faraday cages, and post-hoc digital filtering, which can distort the biological data.

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