Glucose Active Transport |top| -

The kidneys filter approximately 180 grams of glucose per day. To prevent urinary loss, glucose is reabsorbed in the proximal convoluted tubule (PCT) via a synergistic system:

Active transport is defined as the movement of molecules across a cell membrane from a region of lower concentration to a region of higher concentration, requiring cellular energy. glucose active transport

| Parameter | SGLT (Active) | GLUT (Facilitated) | | :--- | :--- | :--- | | | Na⁺ gradient (indirect ATP) | None | | Direction | Against [glucose] gradient | Down [glucose] gradient | | Saturation | Yes (Michaelis-Menten) | Yes | | Inhibition | Phlorizin (specific) | Cytochalasin B | | Na⁺ dependence | Absolute | None | | Concentrating ability | Up to 50x | Cannot concentrate | The kidneys filter approximately 180 grams of glucose

The stoichiometry of the transport varies by isoform and determines the concentrative capacity of the transporter: glucose active transport